Objective：To study the diagnostic value of apparent diffusion coefficient（ADC）in different grades of cerebral gliomas. Methods：A total of 83 cases of glioma were collected from January 2016 to December 2017 in the Department of Neurosurgery of Jiangsu Provincial People’s Hospital. The clinical data of diagnosis and treatment were analyzed retrospectively. All patients were divided into two groups：the low-grade group（Ⅰand Ⅱ grade，23 cases）and the high-grade group（Ⅲ and Ⅳ grade，60 cases）. The difference of ADC values between two groups was compared. Spearman rank correlation test was used to analyze the correlation between ADC values and pathological grades of gliomas. ROC curve was drawn to analyze the diagnostic value of ADC value for high and low grade gliomas. Results：The ADC values in the high-grade cerebral glioma group were significantly lower than those in the low-grade cerebral glioma group（P < 0.05）. There was a negative correlation between ADC values and histopathological grading of cerebral gliomas（r=-0.811，P <0.001）. ROC analysis showed that the area under the ROC curve was 0.976，and the optimal cut-off point of ADC values was 1.19×10-3 mm2 in diagnosing low-grade cerebral gliomas，and the corresponding sensitivity and specificity were 94.80% and 95.70%，respectively；the area under the ROC curve was 0.941，and the optimal cut-off point of ADC values was 1.02×10-3 mm2 in diagnosing high-grade cerebral gliomas，and the corresponding sensitivity and specificity were 94.25% and 95.10%，respectively. Conclusion：ADC values have good diagnostic value for predicting histopathological grade in cerebral gliomas.