Objective：To analysis the efficacy and prognosis of arterial interventional chemotherapy in locally advanced breast cancer patients. Methods：PubMed，The Chinese knowledge network，VIP and Wanfang databases were retrieved to collect all the original literature about “arterial interventional chemotherapy for locally advanced breast cancer” up to August 2018. Then a meta-analysis was carried out on the literatures in accordance with the inclusion criteria. Results：A total of 14 randomized controlled trials（RCT）involving 1 200 patients were included. The results showed that the therapeutic effect of arterial interventional chemotherapy for locally advanced breast cancer was better than that of systemic venous chemotherapy（RR=1.446，95%CI：1.273~1.642，P＜0.05），and the recurrence，metastasis and mortality rates were lower after treatment（RR=0.564，95%CI：0.336~0.946，P＜0.05），and the 5-year overall survival rate was higher（RR=1.239，95%CI：1.097~1.398，P＜0.05），and tend to reduce the incidence rate of systemic adverse reactions（P＜0.05）. Conclusion：Preoperative arterial interventional chemotherapy in patients with locally advanced breast cancer has better therapy responses and prognosis than neoadjuvant systemic venous chemotherapy，and has fewer systemic adverse reactions.