His bundle is a continuation of the atrioventricular node and begins to divide into left and right bundle branches at the top of the interventricular septal muscle. The trunk of His bundle penetrates the central fibrous body and extends to the left bundle branch，which runs below the junction of the noncoronary sinus and the right coronary sinus. Left bundle branches distribute under the endocardium. The right bundle branch is relatively slender and runs on the moderator band. In clinical practice，His-Purkinje system pacing（HPSP）has achieved good results in patients with atrial fibrillation associated with heart failure and heart failure associated with left bundle branch block. HPSP could also maintain ventricular synchrony in ventricular pacing dependent patients. This paper provides a review the anatomy and the application of HPSP.