Objective：This study aims to explore the feasibility and safety of his bundle pacing（HBP）and left bundle branch pacing（LBBP）. Methods：Fifty-nine patients with cardiac pacing were enrolled in the study between May 2017 to Nov. 2018. HBP were performed in group of 19 patients. LBBP were performed in that of 20. Additionally，another 20 patients received right ventricular septum pacing（RVSP）. The successful HBP and LBBP were defined by the characteristic intra-electrocardiograph and paced surface QRS morphology，respectively. The feasibility and the short-term safety of the LBBP’s and HBP’s approach were evaluated. The pace QRS duration was compared among three groups. Results：The successful implanting rates of three different approaches were 79% in HBP group，95% in LBBP group and 100% in RVSP group. The pacing parameters of 3 groups were stable during 3-month follow up. The sensitivity of R wave and pacing threshold in LBBP group seems better than those in HBP group. The pace QRS duration was similar between HBP and LBBP groups；however，the paced QRS duration in RVSP group was significantly broader than those in HBP and LBBP group. Neither complication occurred during this procedure nor in those of follow-up. Conclusion：HBP and LBBP appear to be safe and feasible. LBBP demonstrated with a better sensitivity of R wave and threshold than HBP. Compared to RVSP，HBP and LBBP could maintain better cardiac synchrony.