Objective：This study aims to investigate the concentrations of interleukin（IL）-8 and IL-17 in bronchoalveolar lavage fluid of patients with stable chronic obstructive pulmonary disease（COPD），and analyze their correlations with clinical parameters. Methods：We recruited 109 patients with lung peripheral nodules who visited the Zhongda Hospital Affiliated to Southeast University between Dec.1st 2017 and May 30th 2018，including 79 patients with stable COPD，17 smokers with normal lung function，and 20 healthy non-smokers. Smoking history inquiry，COPD assessment test（CAT），modified Medical Research Council（mMRC）dyspnea index score were collected while spirometry，chest computed tomography and bronchoscopy were performed in all subjects. The levels of IL-8 and IL-17 in BALF were analyzed by enzyme linked immunosorbent assay（ELISA）. Results：The levels of IL-8 and IL-17 in the patients with stable COPD were significantly higher than those of the smokers and the healthy non-smokers（P < 0.01）. The concentration of IL-8 was correlated with IL-17 in all subjects（r=0.929，P < 0.001）and in the COPD patients（r=0.865，P < 0.001）. The levels of IL-8 and IL-17 were negatively correlated with forced expiratory volume in one second（FEV1）and maximum midexpiratory flow（MMEF），while positively correlated with CAT and mMRC. The correlations of IL-8 and IL-17 with emphysema index were significant in the COPD patients with mild emphysema（r=0.559，P < 0.001；r=0.627，P < 0.001），however with no indication among COPD patients with severe emphysema. Conclusion： In stable COPD patients，the levels of IL-8 and IL-17 in bronchoalveolar lavage fluid are increased significantly and correlated with the disease severity. IL-8 and IL-17 have correlation with clinical indicators such as CAT，mMRC，FEV1 and MMEF. The correlations of IL-8 and IL-17 with emphysema index are not significant in COPD patients with mild emphysema.