Objective:This study aims to analyze the severity of left ventricular posterior wall(LVPW) in patients with calcific aortic valve disease,and to evaluate the severity of the lesion and prognosis. Methods:Immunohistochemical staining,semi-quantitative analysis of optical density and RT-PCR were used to detect the calcification degree of valvular tissue in 60 patients with aortic valve calcification,who were divided into mild,moderate and severe aortic stenosis groups. The changes of ejection fraction(EF) before and after operation were compared,and the role of left ventricle post wall(LVWP) in judging the indication of operation and prognosis was evaluated. Results:LVWP in different degree of stenosis group was analyzed,and LVWP in mild,moderate and severe stenosis group was increased in turn,the difference was statistically significant. Through the semi-quantitative analysis of Von Kossa staining of valve tissue and RT-PCR analysis,the calcification degree of LVPW mild,medium and severe thickening group increased in turn,and the difference was statistically significant. The EF difference before and after surgery of patients with LVPW medium thickening was more than that of patients with LVPW mild thickening,and the difference was statistically significant. There was no significant difference in the EF increase in patients with LVPW severe thickening and patients with LVPW medium thickening. Conclusion:LVPW can be used to estimate the approximate degree of aortic valve calcification. For patients with severe calcification of non-aortic valve,the greater the LVPW value,the greater the benefit of surgery.