Objective：This study aims to assess the association between excision repair cross complementing 1（ERCC1）gene polymorphisms（rs3212986、rs11615）and susceptibility to pancreatic ductal adenocarcinoma. Methods：Evidence for this association was obtained by searching PubMed，Web of Science，EMBASE and CNKI. Data were extracted using standardized forms and odds ratios（ORs）with 95% confidence intervals（CIs）were used to assess the strength of association. All statistical analyses were performed using Stata 12.0. Results：Eight studies were enrolled in our final combined analysis. The results showed evidence for significant association between rs3212986 polymorphism and PDAC risk（CA vs. AA：OR=1.34，95% CI：1.11-1.63；CC vs. AA：OR=2.33，95% CI：1.73-3.14；AC+CC vs. AA：OR=1.50，95% CI：1.25-1.80；CC vs. CA+AA：OR=1.98，95% CI：1.50-2.62；C vs. A：OR=1.45，95% CI：1.27-1.66）. However，no association was observed between rs11615 and PDAC risk（CT vs. TT：OR=1.02，95% CI：0.87-1.21；CC vs. TT：OR=1.21；95% CI：0.93-1.56；TC+CC vs. TT：OR=1.06，95% CI：0.91-1.24；CC vs. CT+TT：OR=1.20，95% CI：0.94-1.53；C vs. T：OR=1.08，95% CI：0.96-1.21）. Conclusion：The allele gene C of ERCC rs3212986 is significantly associated with the risk of PDAC，while rs11615 might not contribute to the risk of PDAC.