Objective：To evaluate the effects of different surface treatments on micro-structure and surface roughness of lithium disilicate glass-ceramic. Methods：After being sintered，routinely polished and washed，80 lithium disilicate glass-ceramic plates（12 mm×15 mm×2 mm）were randomly divided into three groups as follows：untreated，as control；sandblasted with 50 μm Al2O3；etched with 9.5% HF. The ceramic plates received different surface treatments were observed with a scanning electron microscope（sem）and their surface roughness were tested by a profilometer. Results：SEM showed that the surface of polished ceramics was relatively smooth，and after hydrofluoric acid treatment，the ceramic surface matrix dissolves，exposing two lithium silicate crystals and intersecting each other，alumina sandblasting after the ceramic surface could be seen irregular shallow concave structure；the measurement results of surface contour meter showed that the surface roughness of ceramics increased significantly after sand blasting and acid etching treatment（P < 0.05）. Conclusion：HF etching and sandblasting can increase the roughness of lithium disilicate glass-ceramic.