Objective：This study aims to analyze the reasons for the removal of levonorgestrel-releasing intrauterine system（LNG-IUS）and the satisfaction of patients，and to explore how to improve the continuous use rate and strengthen the management of patients with LNG-IUS. Methods：The data of 407 patients who voluntarily removed LNG-IUS from January 2015 to June 2018 in our hospital were retrospectively analyzed. According to the reasons for initial LNG-IUS placement in different clinical application，the patients were divided into the contraceptive group and the treatment group. Reasons for removing the LNG-IUS and the satisfaction of patients were compared between both groups. Results：No pregnancy occurred in both groups. The primary reasons for the removal of LNG-IUS in both groups were symptomatic，including amenorrhea and vaginal drip bleeding，and the continued use rate and satisfaction rate of the treatment group were significantly higher than those of the contraceptive group（P < 0.05）. Compared with the treatment group，more women in the contraceptive group removed LNG-IUS due to hormone-related side effects（P < 0.05），which mainly were facial acne and pigmentation（P < 0.05）. Among women with amenorrhea，the placement time was significantly longer and satisfaction rate was significantly higher in the treatment group than in the contraceptive group（P < 0.05）. Conclusion：Different guiding strategies should be given to patients with different clinical applications of LNG-IUS，including detailed notification of various side effects before putting LNG-IUS，follow-up and timely treatment of various side reactions and complications，so as to reduce the rate of LNG-IUS extraction and improve the satisfaction rate of patients.