Relationship between concentration of plasma Lp-PLA2 and cardiac function after acute myocardial infarction
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    Abstract:

    Objective:To study the change of plasma lipoprotein-associated phospholipase A2(Lp-PLA2)concentration in patients with acute myocardial infarction(AMI)and its correlation with cardiac function after AMI. Methods:Ninety consecutive AMI patients who met the study criteria were enrolled. The plasma Lp-PLA2 levels were measured immediately after admission(T0),the next day(T1),the third day(T2),and the seventh day(T3),N-terminal pro brain natriuretic peptide(NT-proBNP)was measured one month after AMI(T4),left ventricular ejection fraction(LVEF)was measured by two-dimensional echocardiography at T1 and T4. Pearson correlation analysis was used to analyze the correlation between Lp-PLA2 and LVEF or NT-proBNP. In addition,48 healthy volunteers and 43 stable angina pectoris patients were enrolled as the controls. Results:The level of plasma Lp-PLA2 showed dynamic changes after AMI,it was increased significantly after the onset of the disease,but decreased to normal level after 7th days of admission[(61.42±36.99)mg/L vs.(49.83±27.17)mg/L,P > 0.05]. The correlation analysis showed that there was no significant correlation between on-admission plasma Lp-PLA2 and C-reactive protein level(r=0.06,P > 0.05)or between Lp-PLA2 and cardiac troponin T level(r=-0.07,P > 0.05). Further studies showed that there was no significant correlation between plasma Lp-PLA2 level at T0 and plasma NT-proBNP level at T4(r=0.16,P > 0.05)or LVEF at T4(r=-0.09,P > 0.05)or the difference of LVEF between T1 and T4(r=0.04,P > 0.05). Conclusion:The plasma level of Lp-PLA2 showed dynamic changes after AMI,which reflected the unstable state of artery plaques,but it was not related to the recovery of cardiac function after AMI.

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吴 鑫,钱焱霞,庞斯斯,徐 冰,王俊宏.血浆脂蛋白相关磷脂酶A2与急性心肌梗死患者心功能的相关性研究[J].南京医科大学学报(自然科学版英文版),2019,(10):1437-1441.

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  • Received:June 25,2019
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  • Online: November 01,2019
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