Study on related factors of non⁃motor symptoms in patients with different motor phenotypes of Parkinson’s disease
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    Abstract:

    Objective:This study aims to compare differences in the incidence and severity of non-motor symptoms in Parkison’s disease(PD) patients with different motor phenotypes,and to further study the influencing factors. Methods:From October 2016 to April 2018,91 patients were diagnosed as primary PD in Jiangsu Subei People’s Hospital were included in this research. PD patients were administrated with non-motor scales and motor scales,including non- Motor Symptoms Questionnaire(NMSQ),Autonomic Symptom Scale(SCOPA-AUT),Hamilton Depression Rating Scale(HDRS),Pittsburgh Sleep Quality Index(PSQI),MoCA,and Mini-Mental State Scale(MMSE),the unified Parkinson’s Disease Rating Scale(UPDRS)Ⅱ and Ⅲ,according to UPDRS Ⅱ and Ⅲ score,all patient were divided in to 12 cases of tremor type(TD),53 cases of postural instability and gait difficulty(PIGD)and 16 cases uncertain type,the differences of scores in the non-motor scales between the TD group and PIGD group were compared,and the influencing factors of the differences were further analyzed. Results:There were no significant differences in age,gender,duration of disease,MMSE,HDRS,FSS,and PSQI scores between the two groups(P > 0.05),education level(P=0.031),age of onset(P=0.038),and H-Y grade(P=0.011),UPDRS-Ⅲ total score(P=0.011),SCOPA-AUT score(P=0.019),NMSQ score(P=0.009)were statistically different. And the influencing factors of the MoCA score,NMSQ score and SCOPA-AUT score was further analyzed,the education level and UPDRS-Ⅲ total score were the influencing factors of MoCA score,P value was <0.001,0.003,respectively;HDRS score and H-Y scale are the influencing factors of SCOPA-AUT score,P value was < 0.001 and 0.044;Age,HDRS score,FSS score and UPDRS-Ⅲ total score are the influencing factors of NMSQ score,P value was 0.031,<0.001,0.008,0.005,respectively. Conclusion:The age,severity of depression,fatigue and motor symptoms are influencing factors of non-motor symptoms,the occurrence of depression and H-Y scale are the influencing factors of the occurrence of autonomic nervous symptoms,and the level of education and the severity of motor symptoms are the influencing factors of the cognitive impairment.

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曹雯燕,刘晓光,马灿灿,陈应柱,任晓梅,张洪英,徐 耀.不同运动表型帕金森病患者非运动症状的相关因素研究[J].南京医科大学学报(自然科学版英文版),2019,(12):1764-1768.

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  • Received:September 23,2018
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  • Online: January 09,2020
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