Objective：This study aims to study the value of leukocyte and procalcitonin on the prognosis of cardiac arrest caused by acute non-infectious diseases in the early stage. Methods：Forty-six patients with cardiac arrest admitted to our hospital from November 2016 to May 2019，who returned to spontaneous circulation by cardiopulmonary resuscitation（CPR）without acute infectious diseases，were selected. They were divided into two groups according to the survival at 30 d after cardiac arrest or not. The correlation between the prognosis and the changes of leukocyte and procalcitonin after cardiac arrest was analyzed statistically. Results：①There was significant difference in the levels of leukocyte and procalcitonin between the two groups in the initial 48 hours after cardiac arrest；② For the death group，the level of leukocyte increased immediately after cardiac arrest，reached the peak around 24 h and decreased in 48 h；③The level of procalcitonin of the death group also increased to the peak about 24 h after cardiac arrest. Conclusion：The level of leukocyte and procalcitonin increased significantly after cardiac arrest. The large increase of leukocyte in 24 h after cardiac arrest may indicate a poor prognosis. However，the procalcitonin level in the early stage and its increase cannot predict the death risk of patients within 30 days after cardiac arrest.