Objective：This study aimed to evaluate the durability of resin bonding to an yttria-stabilized tetragonal zirconia polycrystals（Y-TZP）using two different primers containing phosphate ester monomer ［10-methacryloyloxydecyl dihydrogen phosphate（MDP）］. Methods：A total of 80 zirconia plates were prepared and assigned to 4 groups to build bonded specimens according to surface treatments（sandblasted with alumina particles；sandblasted with alumina particles followed by application of Z-Prime Plus or Clearfil Ceramic Primer；tribochemical silica coating followed by application of silane）. Bonded specimens were built using resin luting cement and tested for shear bond strength（SBS）. X-ray photoelectron（XPS）was used to investigate the formation of chemical bond on the surface of Y-TZP after conditioned with two types of MDP containing primers. Release of the element phosphorus from MDP-mediated Y-TZP/resin-bonded interfaces were evaluated via inductively coupled plasma-mass spectrometry（ICP-MS）. Results：The two types of MDP containing primers increased the SBS in short time，compared to negative control group，the tribochemical silica coating group obtained the highest SBS. After thermocycling，no statistical difference was observed in tribochemical silica coating group，but SBS decreased significantly in groups sandblasted and conditioned with two types of MDP containing primers（P < 0.05）. XPS analysis detected -P-O-Zr bond on the surface of Y-TZP conditioned with MDP-containing primers. Phosphorus was detected by ICP-MS from the solutions used for immersed the Y-TZP/resin-bonded specimens. Conclusion：Water negatively affects bonding between zirconia and resin mediated by MDP-containing primers.