Objective：To investigate the application value of chronic obstructive pulmonary disease（COPD）assessment test（CAT）and monitoring pulse oxygen saturation（SpO2）in management of patients with COPD. Methods：The correlations of CAT，SpO2 during walking，CAT and SpO2（CATS）with pulmonary function were analyzed respectively. The difference of SpO2 was also analyzed between the two groups which were defined as CAT＜10 and CAT≥10. Results：CAT total score，respiratory CAT score，non-respiratory CAT score，SpO2B，SpO2L，ΔSpO2，CATS were all associated with FEV1（forced expiratory volume in 1 second）% predicted. CATS was also associated with non-respiratory CAT score. In CAT＜10 group，non-respiratory CAT score and SpO2B were associated with FEV1%pred. In CAT ≥10 group，CAT total score，non-respiratory CAT score，SpO2L and ΔSpO2 were associated with FEV1%pred. The SpO2B and SpO2L in CAT≥10 group were higher，and ΔSpO2 was lower than those in CAT＜10 group. Conclusion：Monitoring oxygen saturation may be helpful in diagnosis of acute exacerbation of COPD patients. Non-respiratory CAT score contributes more to CAT total score than respiratory CAT score. CATS，the combination of oxygen saturation and CAT，will improve the management of COPD and precision medicine treatment.