The emergence and outbreak of 2019 novel coronavirus（2019-nCoV）have posed a great challenge. Vaccination is an effective way to protect the susceptible from the spread of infectious diseases. The purpose of this essay is to review the inactivated vaccine，subunit vaccine and DNA vaccine research progress of 2002 severe acute respiratory syndrome（SARS）coronavirus and 2012 middle east respiratory syndrome（MERS）coronavirus. Combined with the coronavirus vaccine progress，the history of vaccinia vaccine，and the characteristics of coronaviruses，we provide some potential approachesof vaccine development for 2019-nCoV.