Post-stroke anxiety（PSA）and post-stroke depression（PSD）are common sequelae after stroke，which not only destroys the quality of life of stroke patients，but also greatly interferes with their physical and mental health. There are many biological mechanisms and psychosocial mechanisms for the pathogenesis of post-stroke affective disorders，and different treatment strategies are generated by these different pathogenesis，including drug intervention and non-drug intervention. This article reviews the pathogenesis and clinical treatment of post-stroke affective disorder in recent years.