Objective：This study aims to investigate the relationship between gene polymorphisms of superoxide dismutase 2（SOD2）rs4880，glutathione S-transferase Pi（GSTP1）rs1695 and risk of cervical cancer. Methods： A case-control study was carried out including 395 patients with cervical cancer and 465 case-free controls during the same period. SOD2 rs4880 and GSTP1 rs1695 polymorphisms were examined by TaqMan-Probe assay method. Logistic regression model was used to calculate the odds ratio（OR）and 95% confidence interval（95% CI） between population with different genotypes. Results： When compared with SOD2 rs4880 TT genotype，the rs4880 TC，CC，and TC/CC genotypes might increase cervical cancer risk by 15.1%，96.6% and 18.7%，respectively，but the differences were not statistically significant（OR=1.15，95%CI：0.84~1.57，P=0.378；OR = 1.97，95% CI：0.64~6.09，P=0.231；OR=1.19，95%CI：0.87~1.61，P=0.271）；Compared with the GSTP1 rs1695 AA genotype，individuals with rs1695 AG，GG and AG/GG genotypes showed no significant changes in the risk of cervical cancer（P > 0.05）. Further meta-analysis on the relationship between the polymorphism of GSTP1 rs1695 and cervical cancer also suggested that there was no significant correlation between the genetic variation of rs1695 and the occurrence of cervical cancer. Conclusion：The polymorphisms of SOD2 rs4880 and GSTP1 rs1695 may not be related to the risk of cervical cancer.