Objective：This study aims to investigate the significance of lung lobe quantitative CT parameters in assessment of chronic obstructive pulmonary disease（COPD）. Methods：Total 102 patients with stable COPD were recruited，and performed with chest CT scan and pulmonary function tests. The indexes of pulmonary function include forced expiratory volume（FVC） and predicted value percentage（FVC%pred），forced expiratory volume in one second（FEV1） and predicted value percentage（FEV1% pred），first second rate（FEV1 / FVC），maximum ventilation volume （MVV） and its percentage in the expected value（MVV% pred），maximum mid expiratory flow（MMEF）. The percentages of low attenuation area below -950 HU（LAA%）and airway dimensions in each lung lobe segments were measured quantitatively. Results：Parameters of pulmonary ventilation function were linear negatively correlated with airway indicators（P < 0.001）. When LAA% of left lower lobe was 13.5%，the sensitivity in prediction of MVV% pred <50% and FEV1%pred <50% was 66.2% and 75.0%，specificity was 88.4% and 81.0%，respectively. Wall thickness of 3.35 mm in left lower lobe had 60.5% sensitivity and 72.9% specificity in the prediction of FEV1 <50%. LAA% combined with airway variables could account for proportional changes in FEV1%pred of 42%，FEV1/FVC of 52%，MMEF of 31%，and MVV%pred of 35%，respectively. Conclusion：Quantitative CT parameters of different lung lobe can reflect deterioration of lung function in patients with COPD，and can be applied to predict the severity of airflow limitation.