N6-methyladenine（m6A）is identified as the most abundant internal RNA modification in eukaryotic cells，which depends on proteins that are “writers”，“erasers” and “readers” of m6A. The m6A modification regulates gene expression and plays vital roles in many human diseases，such as cancer，nervous system disease and embryonal growth retardation. This field has become a new research hotspot in the field of epitranscriptomics. In this comprehensive review，we have described the roles played by m6A modification in the development of cancer. Generally，the m6A modification takes part in the self-renewal and differentiation of tumor stem cells，regulates tumor cell proliferation，and is related to chemoradiation resistance. Possible interventions targeting m6A are also discussed in this review，which may be advantageous for precise treatment of tumor.