Analyses of the detection results of allergens among bronchial asthmatic patients with partly controlled or uncontrolled symptoms
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    Abstract:

    Objective:To explore the value of detections for allergens in the management of bronchial asthma. Methods:A total of 108 patients,whose asthmatic symptoms were uncontrolled or partly controlled,were enrolled in this study. The results of inhaled allergens-specific immunoglobulin E(sIgE),food allergens-specific immunoglobulin E,food allergens-specific immunoglobulin G(sIgG)and total immunoglobulin E(IgE)among these patients and their relationship with comorbidities were analyzed. Results:In patients with bronchial asthma,the positive rate of all kinds of allergens-specific immunoglobulins is 82.41% and the positive rates of inhaled allergens sIgE,food allergens sIgE,food allergens sIgG are 58.33%,32.41%,and 56.48%,respectively. The positive rates of inhaled allergens sIgE,food allergens sIgE,food allergens sIgG are 73.33%,30.0%,and 70.0% respectively in the asthmatic patients with allergic rhinitis;66.67%,20.0% and 73.33% respectively in the asthmatic patients with atopic dermatitis;and 48.15%,29.63% and 55.56% respectively in the asthmatic patients with gastrointestinal symptoms. The positive rates of inhaled allergens sIgE and food allergens sIgG are higher than that of food allergens sIgE,and the difference between the overall patients and the asthmatic patients with allergic rhinitis or atopic dermatitis is statistically significant(P < 0.05). The positive rate of inhaled allergens sIgE in patients with total IgE≥100 kU/L is 69.01%,higher than those with total IgE<100 kU/L(37.84%),and this difference is statistically significant(P < 0.05). Conclusion:Asthmatic patients with partly controlled or uncontrolled symptoms should be tested for immunoglobulin of inhalation allergens and food allergens. It is recommended that the tests of inhaled allergens sIgE and food allergens sIgG should be taken in asthmatic patients with allergic rhinitis/atopic dermatitis. In the asthmatic patients with gastrointestinal symptoms,food allergens sIgE should be tested too. For the patients with total IgE≥100 kU/L,testing inhaled allergens sIgE is suggested.

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张雅文,陈良玉,李媛媛,陈佳娣,孙培莉.症状未完全控制的支气管哮喘患者变应原检测结果分析[J].南京医科大学学报(自然科学版英文版),2020,(4):551-556.

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  • Received:September 09,2019
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  • Online: May 08,2020
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