Objective：To explore the value of peripheral blood circulating tumor cells（CTC）combined with ROMA index in the diagnosis of early epithelial ovarian cancer（EOC）. Methods：From June，2017 to April，2019，105 patients with early EOC（malignant group：stage ⅠA and stage ⅠB），152 patients with benign ovarian epithelial tumors（benign group）and 183 healthy women（control group）were selected as subjects. Preoperative venous blood samples were collected and the CTC，human epididymal protein（HE4），and carbohydrate antigen 125（CA125）were measured. The ROMA index was calculated according to the menopausal status of the subjects. The differences of single and combined test results of CTC and ROMA index among the three groups and the differences between theⅠA andⅠB stages of EOC were compared. The efficacy differences in early EOC diagnosesby using CTC and ROMA index and their joint detection were comprehensively evaluated. Results：①The values of CTC and ROMA index，and the positive rates of single or combined detection were all the highest in the malignant group. ②The values of CTC and ROMA index in the ⅠB stage of EOC were higher than those in the ⅠA stage（Z=3.135，P=0.002；t=34.56，P < 0.001）. The difference in the positive rate of combined detection between the ⅠA and ⅠB stages of EOC was statistically significant（χ2=5.24，P=0.02）. ③The specificity and coincidence rate of CTC for early EOC were the highest，but there was no significant difference from those of combined CTC and ROMA detection（P > 0.05）. The combined detection shows the highest sensitivity in the diagnosis of early EOC，and its differences from the single detection of CTC and ROMA index has statistical significance（P < 0.001）. The Youden index of early EOC was the highest by combined detection. The sensitivity，specificity，coincidence rate and Youden index of combined detection are 94.29%，84.18%，86.59%，and 0.785，respectively，showing a relatively high overall efficacy in the diagnosis of early EOC. Conclusion：Single detection of CTC and ROMA index has some significance in the diagnosis of early EOC and the results are correlated with ⅠA and ⅠB staging. Compared with the single detection，combined detection shows a higher comprehensive efficacy in the diagnosis of early EOC and for staging prediction，and thus is of a higher clinical value.