Objective：This study aims to explore the value of general information and chest CT features in the differential diagnosis between mild and severe corona virus disease 2019（COVID-19）. Methods：The general information，chest CT features and CT image changes of follow-up of confirmed 127 patients with NCP from January 1 to February 20，2020，were retrospectively analyzed in Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology，with 101 mild cases（79.53%）and 26 severe cases（20.47%）. The general information and chest CT features of different clinical subtypes were compared using χ2 test or Fisher’s exact probability，and the CT image changes of follow-up were summarized. Results：In 127 COVID-19 patients，73 males（57.48%）and 54 females（42.52%）. There was no significant difference in gender（χ2=1.847，P=0.174）. Compared with the mild cases，the average age of severe cases was older（χ2=4.547，P=0.033. Thirty-two（25.20%）patients had underlying disease，including 15 mild cases（14.85%）and 17 severe cases（65.38%），and there were significant differences in underlying disease between two groups（χ2=28.014，P＜0.001. In terms of CT features，mild cases mainly showed ground glass opacity（67 cases）and mixed ground glass opacity（45 cases），severe cases mainly showed mixed ground glass opacity（19 cases）and crazy paving（10 cases）. There were significant differences in chest CT features between two groups（χ2=11.330，P=0.010）. Mediastinal lymph node enlargement was found in 1 case（3.85%）（P=0.205）and pleural effusion in 4 cases（15.38%）（P=0.001）among severe cases. Compared with the mild cases，the CT grade of lesions in severe cases was generally higher，and the peak of lung involvement was later. Conclusion：There were different chest CT features and CT image changes in COVID-19 patients. Chest CT scan can not only evaluate its clinical course and severity，but also make early warning of severe COVID-19.