Objective：This study aims to summarize the clinical characteristics of liver injury in patients with corona virus disease 2019（COVID-19）. Methods：The clinical data of 93 patients with COVID-19 who were hospitalized in Nanjing Public Health Medical Center were retrospectively analyzed. Results：Among the 93 patients，38（40.9%）had liver injury，including 27 males and 11 females，aged 26-87 years，with an average age of 48. Among these patients with liver injury，the abnormal liver function was manifested as increased total bilirubin（TBIL）and alanine aminotransferase（ALT）/aspartate transaminase（AST），9 patients with abnormal TBIL，25 patients with abnormal ALT/AST，and 4 patients with abnormal TBIL combined with ALT/AST. The increase of TBIL was within 3 times and the increase of ALT/AST within 5 times. Among the 38 patients with liver injury，19（50%）suffered liver injury when admission，and 19（50%）suffered liver injury after admission. The value of TBIL，ALT and AST in the two groups were（16.4±2.0）μmol/L vs.（17.8±2.4）μmol/L（P=0.43），（56.3±8.6）U/L vs.（52.02±6.3）U/L（P=0.69），and（42.8±4.7）U/L vs.（31.92±2.4）U/L（P=0.047），respectively. Conclusion：Among the patients diagnosed with COVID-19，the incidence of liver injury is high and the severity is relatively mild，and most of them can recover by themselves. However，the mechanism of liver injury is complex，and in addition to the liver injury caused by the virus，it may also be combined with drug-induced liver injury，which should be paid attention to in the process of diagnosis and treatment.