Objective：To explore the relationship between lipoprotein-associated phospholipase A2（Lp-PLA2）and insulin resistance in newly diagnosed type 2 diabetes mellitus. Methods：A total of 219 newly diagnosed T2DM patients were selected. Lp-PLA2 levels，total cholesterol（TC），triacyl glycerin（TG），high-density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），glycosylated hemoglobin（HbA1c），fasting plasma glucose and fasting plasma insulin were measured，respectively．Postprandial venous blood samples were collected at 30 and 120minutes after OGTT to test glucose and insulin levels. The patients were divided into normal group（＜200 ng/mL）and high group（≥200 ng/mL）according to Lp-PLA2 level，to analyze the level of insulin resistance between the two groups and their correlation. Results：HOMA-IR in T2DM patients with high Lp-PLA2 level was significantly higher than those with normal Lp-PLA2（P＜0.05），while Matsuda ISI was significantly lower（P＜0.05）.With the increase of Lp-PLA2 level in newly diagnosed T2DM patients，HOMA-IR significantly increased（P＜0.05）and Matsuda ISI significantly decreased（P＜0.05）. Correlation analysis showed that the Lp-PLA2 levels were positively correlated with HOMA-IR（P＜0.05）and negatively correlated with Matsuda ISI（P＜0.05）． Regression analysis showed that Lp-PLA2 was an important predictor for HOMA-IR and Matsuda ISI（P＜0.05）. Conclusion：Lp-PLA2 level is closely related to T2DM insulin resistance. Lp-PLA2，as a simple and feasible indicator，can be useful for evaluating both cardiovascular risk and insulin sensitivity in T2DM.