Objective：To explore the risk factors of sentinel lymph node（SLN）and non-sentinel lymph node（NSLN）metastases in patients with invasive breast cancer. Methods：We retrospectively analyzed the clinical-pathologic characteristics of 845 patients with invasive breast cancer who underwent Sentinel Lymph Node Biopsy（SLNB）in the First Affiliated Hospital of Nanjing Medical University from August 2016 to February 2019. Univariate logistics regression and multivariate logistics regression methods were used to explore the relationship between clinical-pathological parameters and the metastasis of SLN and NSLN. Results：A total of 845 patients were recruited in this study，of which 160 were SLN positive（18.9%）and 685 were negative（81.1%）. Results：of univariate logistic regression analysis：Tumor size，ER status，PR status，lymphovascular invasion，Ki-67，and p53 were risk factors for SLN metastasis. Multivariate Logistic regression analysis results：Tumor size，PR status，lymphovascular invasion were independent risk factors for SLN metastasis. 160 patients with SLN positive patients were further received ALND，among which，NSLN turned out to be negative in 130 cases（81.3%），and positive in 30 cases（18.7%）. Univariate logistic regression showed that PR status and the number of positive SLNs were the risk factors for NSLN metastasis. Multivariate Logistic regression analysis indicated the number of positive SLNs was an independent risk factor for NSLN metastasis. Conclusion：Tumor size，PR status，lymphovascular invasion were independent risk factors for SLN metastases；the number of positive SLNs was an independent risk factor for NSLN metastases.