Tumor is a dynamic pseudoorgan，which contains a variety of cell types，and the interaction between them produces a unique network. In this network，the survival of malignant cells faces many challenges and their metabolic characteristics are reprogrammed accordingly. This change can be experienced and carried out by itself through interaction with other cells in the tumor，especially immune cells. The reconstruction of tumor microenvironment can cause pathophysiological reactions and promote metabolic reprogramming. This metabolic interaction between different cells is used to support tumor metabolism and growth. The importance and universality of these processes and their role in tumor development and progression are being used to design new drug targets and cancer treatments. Therefore，the analysis of the characteristics of different intercellular metabolic reprogramming in tumor microenvironment will help to provide new immunotherapy schemes and strategies，and lay the foundation for individualized precision medical treatment.