Objective：The aim of this study was to analyze the expression of coronavirus-associated genes［angiotensin-converting enzyme 2（ACE2），transmembrane protease serine 2（TMPRSS2），dipeptidyl peptidase 4（DPP4），aminopeptidase N（ANPEP）］in the intestinal mucosa of patients with inflammatory bowel disease（IBD）. Methods：The occurrence of diarrhea in patients with corona virus disease 2019（COVID-19）were collected，and the IBDMDB database was used to analyze the expression of ACE2，TMPRSS2，DPP4 and ANPEP in the intestinal mucosa of IBD patients. Results：The occurrence of diarrhea in COVID-19 patients was 5.8%（136/2 350）. Compared with the rectal mucosa，the difference expression fold of ACE2，TMPRSS2，DPP4 and ANPEP in the terminal ileum were 9.800，0.571，5.318 and 11.127，respectively，with statistical differences（P < 0.05）. However，the expression of these 4 genes did not show significant differences between IBD and non-IBD patients（P > 0.05）. The GO classification showed that these genes were involved in the biological process of the virus entering the host cell，and there was a network interaction between these genes. Conclusion：There is no significant difference in the expression of coronavirus-related genes（ACE2，TMPRSS2，DPP4，ANPEP） in the intestinal mucosa of IBD and non-IBD. We speculate that IBD patients do not have a significantly increased risk of COVID-19.