Objective：To analyze the role of long no-codding RNA（lncRNA）MIR4713HG in the progression and prognosis of colorectal cancer（CRC）by bioinformatics methods，and further predict the possible molecular mechanisms. Methods：The gene expression data and clinical data of CRC were downloaded from The Cancer Genome Atlas（TCGA）database. The data were analyzed by Perl and R software，and the differentially expressed genes were screened. Further，the differential gene survival，independent prognosis and clinicopathological correlation analysis were performed. The most relevant differential gene was selected as the target gene. The correlation between the expression of the target gene and the different clinicopathological features of CRC and its influence on the prognosis of CRC patients were analyzed. The independent prognosis analysis was performed on different clinicopathological features by R software. Gene set enrichment analysis（GSEA）enrichment analysis of the target gene was used to predict the possible mechanism by which the target gene regulated the progression and prognosis of CRC. Results：By analyzing the gene expression data，we obtained 7 866 differentially expressed genes. The correlation analysis of differential gene survival，independent prognosis and clinicopathological features found that MIR4713HG was significantly associated with survival prognosis and clinicopathological features of CRC. MIR4713HG was used as the target gene. MIR4713HG was found to be highly expressed in CRC tissues by TCGA database（P < 0.001）. MIR4713HG was associated with CRC grade and TNM stage（P < 0.05），but no age correlation with patients（P=0.999）. Independent prognostic analysis suggested that the prognosis was associated with MIR4713HG，age，tumor grade，TNM stage（P < 0.05），MIR4713HG and age as independent risk factors for evaluating patient prognosis. GSEA enrichment analysis showed that MIR4713HG was enriched in the P53 signaling pathway. Conclusion：The gene of lncRNA MIR4713HG can be used as a target for evaluating the progression and prognosis of CRC，which may play a role through the P53 signaling pathway.