Objective：To study the correlation between physical fitness indexes and cardiovascular disease（CVD）. Methods：We selected the physical examination data of the male physical examination population（a total of 220 males，of which，baPWV was tested in 142 males）who underwent physical fitness in our hospital from January 2018 to July 2019. Based on the scores of Framingham CVD 10-year risk，the total people were divided into groups with low-risk and middle-high risk；according to the speed of baPWV，the people who completed the test were divided into normal group and fast group. The correlation between physical fitness indexes and CVD 10-year risk，baPWV was analyzed. Results：There were significant differences in age，smoking proportion，cardiorespiratory fitness，body fat percentage，single foot stand time，blood pressure，fasting blood glucose（FBG），glycosylated hemoglobin（HbA1c）and triglyceride（TG）between the middle-high risk group of CVD，baPWV accelerated group and the low risk group of CVD，baPWV normal group（P < 0.01 or P < 0.05）. The middle-high risk of CVD and increased baPWV were correlated with age，body mass index（BMI），cardiorespiratory fitness，body fat percentage，single foot stand time，systolic pressure，diastolic pressure，FBG，HbA1c and TG（P < 0.01 or P < 0.05）. Conclusion：Age，smoking，body fat percentage，blood pressure，FBG，HbA1c and TG are the risk factors of CVD. Cardiorespiratory fitness is the protective factor of CVD，which has a good predictive value for the risk of cardiovascular disease.