Objective：To investigate the relationship between lipoprotein-associated phospholipase A2（Lp-PLA2）levels and vascular endothelial function and arterial elasticity in type 2 diabetes mellitus（T2DM）patients. Methods：A total of 163 individuals with T2DM who were admitted to the First Affiliated Hospital of Nanjing Medical University were enrolled. Latex scattering immunoturbidimetric assay was used to determine plasma Lp-PLA2 levels. Noninvasive peripheral arterial tone measurement（PAT）was performed to evaluated endothelial function by reative hyperemia index（RHI），and pulse wave velocity（PWV）were used to determine the arterial elasticity. Results：In T2DM patients，the vascular endothelial function index（RHI）gradually decreased with the increase of LP-PLA2 level（r=-0.23，P＜0.01），whereas there is no significant correlation between Lp-PLA2 and PWV（r=0.13，P=0.17）. Further multiple linear regression analysis showed that Lp-PLA2 remained as an independent factor for RHI after adjusting for age，gender，LDL-cholesterol，glycosylated hemoglobin，smoking，and body mass index（β=-0.231，P=0.027）. Conclusion：Plasma Lp-PLA2 may be a suitable surrogate marker for evaluation of vascular endothelial function.