Objective：This study aims to investigate the clinical value of shear wave elastography combined with contrast-enhanced ultrasound in the diagnosis of breast lesions. Methods：There were 159 patients，a total of 171 breast lesions enrolled by ultrasound in our hospital from January 2016 to September 2018. The conventional ultrasound，shear wave elastography and contrast-enhanced ultrasound were performed before operation. Taking the pathology as the golden standard，and the ROC curve was drawn. The diagnostic efficacy of conventional BI-RADS classification，shear wave elastography，contrast-enhanced ultrasound and the joint score in the diagnosis of benign and malignant breast lesions were compared，and the clinical value of shear wave elastography combined with contrast-enhanced ultrasound in the diagnosis of breast lesions was summarized. Results：According to the ROC curve，the diagnostic value of shear wave elastography，contrast-enhanced ultrasound and the joint method were obtained，respectively. The diagnostic sensitivity，specificity，accuracy and area under the curve of single method were 85.96%，75.44%，82.46%，0.807；94.74%，71.93%，87.13%，0.833 and 97.37%，75.44%，90.05%，0.864，respectively. The combination has the highest detection rate of malignancy and the highest diagnostic efficiency. Conclusion：Shear wave elastography combined with contrast-enhanced ultrasound improves the diagnostic efficacy of breast lesions and has great diagnostic value for benign and malignant breast tumors.