Objective：This study aims to explore the application value of different combined schemes of S-Detect technique and conventional ultrasound in the evaluation of breast nodules. Methods：The routine ultrasound images of 175 breast nodules from May 2019 to April 2020 were collected. BI-RADS category was performed by low-，middle-and senior-aged sonographers before the surgery，and adjusted by four different schemes combined with S-Detect results. The pathological results were used as the gold standard after surgery to evaluate the S-Detect diagnostic value，and compare the diagnostic efficacy of sonographers with different seniority before and after combining different schemes. Results：The diagnostic specificity of S-Detect alone was higher than that of sonographers，and the difference was statistically significant（P < 0.01）. AUC value of combined diagnosis of low- and middle-aged sonographers significantly increased，and it was statistically significant（P < 0.01），among which the combination of schemes Ⅲ and Ⅳ was significantly better than schemes Ⅰ and Ⅱ（P < 0.05）；AUC value decreased after the combination of senior-aged physicians. Conclusion：S-Detect technique had high diagnostic specificity. Low- and middle-aged sonographers combined S-Detect technique with BI-RADS category could improve their diagnostic efficiency，among which the combination of scheme Ⅲ and Ⅳ performed better.