Objective：This stndy aims to explore the death characteristics and trends caused by four main chronic noncommunicable diseases（NCDs）among residents between 30 and 69 years old in Wujin District of Changzhou from 2009 to 2019，to provide suggestions and basis for realizing the goal of decreasing the probability of premature mortality of“Health China 2030”major NCDs in this region. Methods：The mortality rate of four major NCDs were analyzed for residents between 30 and 69 years old，the average annual percent change（APC）was used to describe the change trend，and premature mortality probability of major NCDs was calculated on the basis of the life table，the effects of demographic factors and non-demographic factors were analyzed by differential decomposition analysis. Results：In 2009—2019，the crude mortality rate of major NCDs among residents between 30 and 69 years old decreased at the rate of APC=-2.01%（P＜0.001）. The standardized mortality of malignant tumor，cardio-cerebrovascular disease，chronic respiratory diseases going down with APC=-3.62%（P＜0.001），APC=-3.80%（P＜0.001），APC=-6.61%（P=0.004）respectively，while the standardized mortality of diabetes increased year by year（APC=4.19%，P=0.022）. The premature mortality of major NCDs decreased from 12.32% in 2009 to 8.91% in 2019，while the premature mortality of diabetes showed a slightly upward trend. The decrease of crude mortality caused by non-demographic factors in the four major NCDs of residents aged 30 to 69 obviously outweighed the increase of crude mortality caused by demographic factors，but for the change of male diabetes mortality，both demographic factors and non- demographic factors contributed to the increase of mortality. Conclusion：The premature mortality of major NCDs residents between 30 and 69 years old is on the decline. However，in general，the prevention and control of major NCDs is still grim，and the prevention and control of diabetes is particularly important in terms of preventing premature death.