Hypertension is closely related to the occurrence and development of cerebrovascular diseases，such as stroke and heart failure. Intensive blood pressure control can reduce the morbidity and mortality of related diseases. However，the awareness rate，diagnosis rate，treatment rate of hypertension and control rate of hypertension are still not satisfactory. The reasons of low control rate mainly include the unclear pathogenesis，the diversification of first-line drugs，and the varied response for different population. In recent years，metabolomics studies have provided new perspectives for the pathogenesis of hypertension，biomarker screening，pharmacological action of related drugs，efficacy and safety assessment of medication. In this paper，the research methods and the results of metabolomics research related to hypertension and antihypertensive drugs are reviewed，so as to provide reference for further research.