Bone metabolic dynamic balance plays an important role in maintaining normal bone tissue function，and the disruption of this balance can lead to bone metabolic diseases. The mechanism of bone metabolism is still unclear，and the signaling pathway is complex. Canonical Wnt signaling plays multiple roles in bone development and bone metabolism，which is closely related to osteogenic differentiation of mesenchymal stem cells，proliferation and differentiation of osteoblasts and osteoclasts. This review summarizes the mechanism of Wnt/β-catenin signaling pathway in bone metabolism and its research progress in bone metabolic diseases，in order to explore new ideas and approaches in the prevention and treatment of bone metabolic diseases.