Objective：To investigate the alterations of functional connectivity among Parkisnon’s disease（PD）patients with anxiety，and to explore its pathological mechanism. Methods：Totally 112 PD patients and 54 healthy controls underwent rs-fMRI scanning. According to the Hamilton anxiety scale（HAMA），112 PD patients were divided into 50 PD with anxiety group（PD-A）and 62 PD without anxiety（PD-NA）. ANCOVA and post-hoc t test were performed to assess intergroup difference of voxel-mirrored homotopic connectivity（VMHC）value to obtain the abnormal brain regions. Bilateral amygdala were chosen as seeds to calculate functional connectivity with abnormal brain regions. Estimated a Pearson’s correlation coefficient between functional connectivity calculated above and HAMA scores. Results：VMHC value had significant differences among three groups，post hoc t test showed a decrease of VMHC value in bilateral inferior frontal gyri（IFG）triangular part and opercular part in PD-A group compared to the PD-NA group. Functional connectivity increased between the left amygdala and the left IFG. Furthermore，functional connectivity was positively correlated with HAMA scores. Conclusion：Abnormal brain functional activity exists in PD-A group，suggesting that anxiety in PD is associated with abormalities in IFG-amygdala loop network.