Objective:To observe the effect of radiotherapy dose on cervical esophageall carcinoma,and to analyze the prognostic factors of cervical esophageal carcinoma. Methods:A retrospective analysis was performed on 96 patients with cervical esophageal carcinoma who received three dimensional conformal radiation therapy or intensity-modulated radiation therapy from 2013 to 2018 according to inclusion criteria. All the patients are divided into three groups according to the radiation dose of gross tumor:the low-dose group(≤60 Gy),the medium-dose group(>60~<66 Gy)and the high-dose group(≥66 Gy)respectively. The clinical effect,acute adverse effects,and treatment failure mode were compared among three groups,and the prognostic factors of cervical esophageal carcinoma were analyzed. Results:The short-term efficacy was observed one month after radiotherapy,and the objective response rate was 66.7%,85.4%,and 85.7%,respectively. There was no statistical difference among three groups(P=0.114). The univariate analysis showed that radiotherapy dose was the influencing factor of overall survival(P=0.031),progression-free survival(P=0.045)and local-regional failure-free survival(P=0.020),and there was no difference in the efficacy between the middle-dose group and the high-dose group,and all of them better than the low-dose group(P<0.05). The independent prognostic factors of OS for cervical esophageal carcinoma are radiotherapy dose,synchronous chemotherapy,and invasion of adjacent organs. Conclusion:Radical chemoradiotherapy is effective for cervical esophageal cancer,and the medium dose,i.e. >60~<66 Gy,may be a more reasonable radiotherapy dose for cervical esophageal cancer. Radiotherapy dose,concurrent chemotherapy and invasion of adjacent organs are independent prognostic factors of OS.
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LIU Jia, CUI Zhen, SUN Qiaoyu, JIANG Hao, LI Duojie, FAN Xiaodi. Effects of radiotherapy dose on cervical esophageal carcinoma and related prognosic factors analysis[J].,2021,(4):557-563.