Objective：This study aims to observe the expression and possible mechanism of a disintegrin and metalloproteinase 15（ADAM15）in asthma. Methods：The clinical data and serum samples of 32 asthma patients and 16 healthy controls were collected，enzyme-linked immunosorbent assay was used to detect the expression of serum ADAM15，and the correlation of peripheral blood eosinophils count and percentage，serum total IgE with ADAM15 was analyzed. A mouse model of OVA-induced allergic asthma was constructed，using immunohistochemistry to observe the expression of ADAM15 expression in lung tissue. Real-time quantitative PCR and Western blotting were used to detect the effect of different cytokines stimulation on the expression of ADAM15 in human bronchial epithelial cell line 16HBE. Results：The level of serum ADAM15 in the asthma group was higher than in the healthy control group［（749.5±132.3）pg/mL vs.（398.90±22.13）pg/mL，P=0.023］. ADAM15 is mainly expressed in bronchial epithelial cells in mouse lung tissue. After 24 hours of stimulation of exogenous IL-13（10 ng/mL），the mRNA and protein levels of ADAM15 were up-regulated. Conclusion：The expression of ADAM15 is elevated in asthma，and may be related with the IL-13-mediated airway inflammation.