The correlation between serum vitamin D binding protein and chronic kidney disease
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    Abstract:

    Objective:This study aims to explore the relationship between serum vitamin D binding protein(DBP) level and the occurrence of chronic kidney disease (CKD),further establish a clinical risk prediction model for CKD and evaluate its predictive power for CKD. Methods:The patients who were hospitalized in the department of nephrology between March 2020 and September 2020 were selected. The serum DBP levels of the patients were detected by the ELISA method. The relationship between serum DBP and CKD related indicators was anacyzed. And the clinical data of the high DBP group and low DBP group were compared. A clinical risk prediction model including DBP was construct and its effectiveness was evaluated in predicting the occurrence of CKD. Results:Compared with the normal control group and CKD stage 3 patients,the serum DBP levels of patients with CKD stage 4 and CKD stage 5 were significantly lower. Serum DBP and CKD related indicators and interventions have obvious correlation. Compared with the comprehensive clinical risk prediction model A(AUC=0.917,95% CI:0.849~0.985,P<0.001),the comprehensive clinical risk prediction model B(AUC=0.942,95% CI:0.894~0.991,P<0.001) increased the serum DBP as a predictor variable,and significantly improved the AUC and,specificity for predicting CKD. Conclusion:Serum DBP decreases significantly in CKD 4-5 stages,which are correlated with the occurrence of CKD. The addition of the predictive variable of serum DBP significantly improves the predictive performance of the model in predicting CKD and helps to screen high-risk patients with CKD.

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彭 慧,李屾森,邢红霞,李汶汶,曹长春.血清维生素D结合蛋白与慢性肾脏病发生的相关性[J].南京医科大学学报(自然科学版英文版),2021,(5):690-695.

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  • Received:February 03,2021
  • Online: June 02,2021
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