Objective：This study aims to investigate the diagnostic value，safety and feasibility of CT- guided percutaneous lung biopsy for hilar nodules less than 3.0 cm. Methods：The data of patients with the nodules of lung hilum without positive results from fibrobronchoscopy undergoing CT guided lung biopsy in our hospital from 2016，July to 2020，February were collected. The size and shape of the lesion，the length of the puncture path，the needle angle，cutting times and complications were recorded. Results：Total 62 patients were enrolled in the study. All cases were successfully conducted in the first biopsy including adenocarcinoma（n=29），squamous cell carcinoma（n=14）， small cell lung cancer（n=4）， specific infection（n=2）， mixed cancer（n=6），metastatic cancer（n=1），and undetermined lesions（n=7）. The accuracy rate，sensitivity and omission diagnostic rate was 98.44%（63/ 64），98.21 %（55/56）and 1.79%（1/56），respectively. The main complications were pneumothorax and pneumorrhagia，the incidence rates of which were 15.63%（10/64）and 43.75%（28/64），respectively. The length of the puncture path is important factor for two complications. The age and gender of patients are correlated with the incidence of pneumothorax. The cutting times and the shape of lesion are correlated with the incidence of pneumorrhagia. Conclusion：CT-guided percutaneous lung biopsy has higher diagnostic value and better safety for lung hilar nodules，playing a good guiding role in clinical diagnosis and treatment.