Objective：To evaluate the risk factors of early neurological deterioration（END）in patients with acute minor ischemic stroke，and to construct a nomogram model of END. Methods：From April 2015 to June 2018，the clinical data of the patients with acute minor ischemic stroke in Nanjing First Hospital and Nantong Third People’s Hospital were prospectively collected. Demographics and baseline clinical data were compared between the END group and the non-END group. We used the multivariate logistic regression analysis to determine the independent risk factors for END. Based on these independent factors，we constructed the nomogram of END in patients with acute minor ischemic stroke. Results：A total of 507 patients were enrolled in the study. The age（P=0.001），atrial fibrillation（P=0.001），ischemic heart disease history（P=0.010），baseline NIHSS（P=0.023），fasting blood glucose levels（P=0.001）and hypersensitivity C-reactive protein levels（P=0.006）in the END group were significantly higher than those in the non-END group，and drinking history（P=0.042）as well as the albumin levels（P=0.001）were significantly lower than those in the non-END group. Multivariate logistic regression analysis showed that age［odds ratio（OR）1.031，95% confidence interval（95% CI）1.008~1.054；P=0.007］，atrial fibrillation（OR=4.349，95%CI：1.932 ~9.792；P=0.001），baseline NIHSS（OR=1.219，95%CI：1.021~1.455；P=0.029），fasting blood glucose（OR=1.199，95%CI：1.083~1.328；P=0.001），high sensitivity C-reactive protein（OR=1.069，95%CI：1.027~1.113；P=0.001），albumin（OR=0.826，95%CI：0.733~0.930；P=0.002）were the independent risk factors for END. Based on the independent risk factors，a nomogram model was constructed，and the consistency index was 0.736（95%CI：0.677~0.796，P < 0.001）. Conclusion：This nomogram has a certain predictive value for END in patients with mild acute ischemic stroke.