Objective：The clinical manifestations of patients with anti-N-methyl-D-aspartate receptor（anti-NMDAR） encephalitis in East China and factors associated with prognosis were analyzed. Methods：A retrospective study of 106 patients（58 females，48 males）with anti-NMDAR encephalitis in East China was carried out from June 2015 to February 2020. Clinical features and factors influencing outcomes were reviewed. Results：Behavioral changes were observed in 74.5%（79/106）of patients，and comprised the initial symptoms in 61.3%（65/106）. Seizures were observed in 67%（71/106） of patients，and served as initial symptoms in 31.1%（33/106）. A total of 54.9%（39/71）of seizures were focal seizures. The patients with high cerebrospinal fluid（CSF）antibody titers experienced more clinical symptoms than those with low CSF antibody titers. One hundred and fourteen electroencephalography（EEG） or video EEG recordings were obtained from 92 patients. EEG background activity（BA） was significantly aggravated at 12 days. A total of 72.5%（74/102）of patients showed normal magnetic resonance imagings（MRIs）. Brain lesions were observed in 27.45% of patients（28/102）. During the peak stage of the disease，focal high blood flow with normal MRIs were observed from 56.52%（13/23） arterial spin labeling（ASL）of anti-NMDAR encephalitis patients. Focal high blood flow with brain lesions were observed in 39.13%（9/23）ASL of patients. The binary logistic regression analyses revealed the factors associated with poor outcomes included consciousness disturbance，EEG BA，number of symptoms and CSF antibody titer. Conclusion：EEG BA and number of symptoms are associated with CSF antibody titers. Consciousness disturbances，EEG BA，number of symptoms and increasing CSF antibody titers served as predictors of poor outcomes.