Objective：This study aims to evaluate the safety and efficiency of the percutaneous left atrial appendage occlusion（LAAO） in nonvalvular atrial fibrillation（NVAF） patients with coronary heart disease（CAD）. Methods：Total 51 NVAF patients were consecutively accepted LAAO from June 2015 to July 2017. Patients were divided in two groups：15 with CAD and 36 without CAD. All patients were followed up after discharge with transesophageal echocardiography（TEE） examination. Results：Patients with CAD had higher incidence of hemorrhagic stroke or major bleeding than those without CAD. The incidence of end-point events had no statistical difference between CAD group and non-CAD group. Compared with CAD patients who accepted long-term antithrombotic medication，there was a further reduction of hemorrhage in CAD patients who accepted LAAO group. Moderate or severe left atrial spontaneous echo contrast was correlated with the composite end point events. Conclusion：There are similar safety and effectiveness for LAAO procedure in NVAF patients with or without CAD. Meanwhile，left atrial spontaneous echo contrast is a predictive factor of LAAO in NVAF patients combined CAD.