Control of cholesterol levels can reduces the incidence of atherosclerotic cardiovascular disease（ASCVD）. Increased low-density lipoprotein cholesrerol has been an independent risk factor of ASCVD. Statins，cholesrerol absorption inhibitor，bile acid sequestrant have been proved effectively for reduction of low-density lipoprotein cholesterol. New type therapeutic drugs proprotein convertase subtilisin/kexin type 9 inhibitors，microsomal triglyceride transfer protein inhibitor，antisense oligonucleotide inhibitors，peroxisome proliferator-activated receptor-α have also achieved clinical benefit in recent clinical trials. In this article，we will review the efficacy and safty of cholesterol-lowering drugs，so that we can find out the most effective plan of cholesterol management.