Long non-coding RNA（lncRNA） is a kind of nucleic acid molecule which is transcribed from the mammalian genome and lacks protein-coding potential，it mainly realizes the regulation of gene expression from three aspects of epigenetics，transcriptional regulation and post-transcriptional regulation，or directly participates in regulating protein activity. With the development of sequencing technology，it has been found that lncRNA can be used as miRNA sponge to further regulate mRNA expression，and the lncRNA-miRNA-mRNA axis plays an important role in the pathogenesis of diseases. Current researches confirm that the lncRNA-miRNA-mRNA axis is closely related to the pathogenesis of cardiovascular diseases. In this review，we summarize the latest developments in the known roles of this axis in the pathogenesis of cardiovascular diseases.