Objective：This study aims to clarify the effects of H19 genetic variant rs2839698，rs217727，rs3741216 and rs3741219 on renal cell carcinoma（RCC） susceptibility and prognosis. Methods：We conducted this two-stage case-control study with a total of 1 014 RCC cases and 1 063 controls since May 2004. Total 298 RCC cases in the first stage had complete follow-up data available. Genotyping was performed using TaqMan real-time polymerase chain reaction assays. Odds ratio（OR）and 95% confidence interval（CI） were calculated to evaluate the association between H19 polymorphism and RCC risk and clinical characteristics. Kaplan-Meier method was utilized to assess the survival of H19 polymorphisms. Hazard ratio（HR）and 95%CI were calculated by COX regression model to discover whether genotypes，TNM and grade were the independent prognostic factors. Results：Compared with the H19 rs2839698 CC genotype，the variant genotypes（CT/TT）were significantly associated with increased risk of RCC（P=0.012，OR=1.13，95% CI=1.02-1.55）. Besides，patients with variant genotypes（CT/TT）were more likely to develop large tumor（P=0.003，OR=1.35，95% CI=1.10-1.73）and advanced disease（P=0.010，OR=1.63，95% CI=1.08-2.21）；and had a significantly unfavorable 5-year survival than those with the rs2839698 CC genotype（CT/TT vs. CC：Log-rank P=0.027，HR=2.24，95%CI=1.10-4.59）. Conclusion：The results suggested that H19 rs2839698 variant may be a genetic predictor of susceptibility and mortality of RCC. The precise functional impact of the variant on H19 still needs further experimental validation.