Objective：This study aims to analyze the clinical features of patients with sepsis secondary to liver abscess and find the early diagnostic indicators. Methods：A total of 237 patients with liver abscess diagnosed and treated in the First Affiliated Hospital of Nanjing Medical University from January 2017 to April 2021 were selected as the research subjects. They were divided into two groups：the non-sepsis group and the sepsis group，and the clinical characteristics of the two groups were analyzed. The data was analyzed using SPSS 22.0. Results：Diabetic patients were more prone to liver abscess（72.6%）. Patients in the sepsis group were retrospectively evaluated according to qSOFA. Compared with the non-sepsis group，the differences in respiratory rate ≥22 cpm（0.007），GCS<13（P < 0.001）and systolic blood pressure were statistically significant. The white blood cell count of patients with sepsis group［（13.81±6.89）×109/L vs. （10.91±6.89）×109/L，P < 0.001］，the neutrophil ratio［（84.29±8.15）% vs. （79.86±12.68）%，P=0.021］，C-reactive protein（P=0.048）and procalcitonin（P < 0.001）were higher than those in the non-sepsis group. Blood glucose control was worse in the sepsis group（P=0.016）. There was no difference in abscess growth location and bacteriological culture between the two groups. The leading cause of liver abscess was Klebsiella pneumoniae（76.8%）. Conclusion：Diabetic patients are prone to secondary liver abscess. The qSOFA can be used for the early judgment of the severity of liverabscess. WBC count，neutrophil ratio，C-reactive protein and procalcitonin can be used for early diagnosis of liver abscess and further prediction of disease development. Klebsiella pneumoniae is the main pathogen of liver abscess.