Objective：This study aims to explore the difference between hepatic-specific contrast agent（Gd-EOB-DTPA） and conventional contrast agent（Gd-DTPA） in predicting microvascular invasion（MVI） of hepatocellular carcinoma（HCC） based on MR imaging features. Methods：A retrospective analysis of 253 patients with HCC who underwent surgical treatment from January 2010 to January 2019（121 cases in Gd-DTPA group and 132 cases in Gd-EOB-DTPA group） were carried out. The preoperative MR imaging features were evaluated，and MVI-prediction models were established through multi-factor logistic regression. Effectiveness and differences of the models were assessed with receiver operating characteristic curves and clinical decision curves. A postoperative survival analysis was also conducted. Results： Lesion size， border invasion in both Gd-DTPA and Gd-EOB-DTPA group， and satellite lesions in Gd-EOB-DTPA group， are independent risk factors for predicting MVI. The area under the curve（AUC） of two models were AUCGD-DTPA：0.761 and AUCGD-EOB-DTPA：0.791， respectively. The clinical decision curve shows that Gd-DTPA and Gd-EOB-DTPA have similar clinical benefits in predicting MVI. Survival analysis illustrated that there were significant difference on the average disease-free survival time between the MVI-positive group and the MVI-negative group not only confirmed by histopathology but also predicted by the models. Conclusion：Lesion size，border invasion and satellite lesions are independent risk factors for predicting MVI. The application of Gd-EOB-DTPA could not obtain more clinical benefits than Gd-DTPA in predicting MVI，but Gd-EOB-DTPA has a higher sensitivity.