Objective：This study aims to observe the condition of post-procedure heart blocks after transcatheter closure of perimembranous ventricular septal defect（pmVSD） under the guidance of the new treatment strategy of transcatheter closure of pmVSD based on previous experience. To investigate the risk factors and prevent post-procedure heart blocks. Methods：The clinical data of the 196 patients who successfully underwent transcatheter closure of pmVSD from January 2012 to July 2020 were analyzed. Univariate and multivariate logistic regression models were used to analyze and explore the risk factors. Results：Total 18 patients（18/196，9.2%）developed post-procedure heart blocks，including complete and incomplete right bundle branch block，left anterior fascicular block，intraventricular block and first degree atrioventricular block. No complete left bundle branch block and high-degree atrioventricular block occurred. All post-procedure heart blocks recovered within 2 months. The incidence of heart blocks in the basal occlusion group（12.7%，17/134）was higher than the intratumoral occlusion group（1.6%，1/62）（P=0.014）. The analysis of basal occlusion group showed that distance from the aortic valve to the defect（DAVD）（P=0.015）and the diameter of the defect（P=0.022）were positively related to post-procedure heart blocks. Conclusion：The incidence of heart blocks is higher in the basal occlusion group. In the basal occlusion group，DAVD and the diameter of the defect are independent risk factors of post-procedure heart blocks.