Objective：This study aims to investigate the predictive value of first-time high-sensitivity troponin T（hs-TnT）in patients with acute myocarditis to receive extracorporeal membrane oxygenation（ECMO）support. Methods：A retrospective study was conducted for 98 patients with acute myocarditis. They were divided into ECMO group（n=32） and non-ECMO group（n=66）. Baseline data，level of serum hs-TnT and N-terminal pro-B type natriuretic peptide （NT-proBNP） were collected and compared. Results：Total 98 patients were finally enrolled. The levels of serum hs-TnT- and NT-proBNP- in ECMO group［3 580（1 656，8 935）ng/L，10 577（3 701，24 164）pg/mL］were significantly higher than those in non-ECMO group［630（180，1 496）ng/L，565（240，3 736）pg/mL］ ，respectively（P < 0.001）. Logistic regression analysis showed first-time hs-TnT（OR=1.290，95%CI：1.024~1.626，P=0.031）and NT-proBNP level（OR=1.081，95%CI：1.019~1.146，P=0.009） were independently risk factors of ECMO therapy. Conclusion：The first-time hs-TnT and NT-proBNP level in patients with acute myocarditis could be used to predict whether the patient needs ECMO support.